77 / 100 SEO Score

Nootropics are a hot topic these days, and that comes as no surprise. These supplements can boost your brainpower, improve mood, and provide neuroprotection.

Some people choose to combine two or more nootropics to potentiate their benefits. However, combining the wrong ones can lead to side effects.

In this article, we’ll tell you more about nootropics, along with answering your question: “what nootropics should not be mixed?”.

What are Nootropics?

For anyone unfamiliar with nootropics, let’s quickly go over what they are.

Nootropics are supplements designed towards boosting your mental performance. This includes things like:

  • Focus
  • Mood
  • Memory
  • Word Recall
  • Creativity

And more. Just like any supplement, not all nootropics are the same.

Some focus on improving your focus and motivation so you can excel at various mental tasks. Other nootropics work to calm you down and support your mood. Then there are nootropic formulas, which combine multiple nootropic ingredients to promote long-range brain wellness and cognitive strength.

Types of Nootropics

You’ll mainly find two types of nootropics out there: synthetic and natural.

Synthetic nootropics are manmade. While some of them can offer benefits, there’s also a risk of side effects.

However, you’d be forgiven for thinking that natural is always safer. Sometimes that isn’t the case – especially when you’re mixing more than one nootropic.

What Nootropics Should Not Be Mixed

With so many nootropics out there, it’s easy to get confused about what ones shouldn’t be mixed. The best way to find out about specific nootropic interactions is by doing proper research and consulting with a qualified professional.

Luckily, we do know about specific categories of nootropics that are generally not well tolerated when mixed. The riskiest group is without doubt stimulants.


There are various stimulant nootropics out there. The most common one is caffeine. It binds to your adenosine receptors and makes you more alert.

Caffeine also increases your dopamine, adrenaline, and other stress hormones – putting you ‘in the zone’ mentally. Take too much of caffeine, though, and these benefits will quickly turn into side effects. Including:

  • Irritability
  • Anxiety
  • Nausea
  • Insomnia
  • Jitters

These side effects can also occur when you mix caffeine with other stimulants such as bitter orange peel, yohimbine, Adderall, or others. This is because they all share similar effects. (3)


Racetams are generally well tolerated by most people. And have a high toxicity threshold. Still, specific individuals will negatively react to these lab-made compounds. (2)

The problem with racetams is the lack of long-term human research. Most of the studies we have on racetams, including piracetam (the grandfather of nootropics you could say), are short-term or involve animals.

Because long-term effects aren’t known, we can’t tell how safe these nootropics really are. Let alone how safe it is to combine racetams.